The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

The Effect of Allopurinol on Endothelial Function, Serum Uric Acid and NT-proBNP in Acute Decompensated Heart Failure


Acute decompensated heart failure has an increasing incidence and poor prognosis, being a major cause of death and hospital readmission and requiring urgent optimized therapy[1]. Under the influence of some decompensation risk factor, such as infections, arrhythmias, decompensation of some comorbidities, lack of adherence to the treatment, patients with a history of heart failure may suffer a progressive symptomatology worsening
therefore, more than 70% of cases of acute heart failure represent the clinical worsening of chronic heart failure – ADHF[2]. […]