Pathological modifications of the large joints (knee, hip, shoulder, ankle) due to trauma and/or inflammation are a common occurrence, which increases as the general population gets simultaneously older and more active[1]. Progress in this therapeutic area has not kept up with the increased need for more effi cient treatments, an overall consideration which includes efficacy in reducing discomfort, cost of treatments, presence of adverse reactions and the long term effects on the function and structure of the joints, which may prompt the need for repeated or different treatments. […]