As a response to the COVID-19 pandemic, medical universities were closed in Romania, between March 2020 and July 2020. The educational process was transferred to an on-line environment, in person contact becoming nonexistent outside the group of people from one’s household. The purpose of this study is to provide an overview of the mental health status in medical undergraduates in Romania during lockdown. A questionnaire was used in April 2020 to collect information regarding the life of students during social isolations and to assess the mental health of students using a self-reported 1-7 scale on 21 relevant endpoints. After data quality control, the remaining 1978 data entries were analysed in SPSS 20. We identified multiple factors that may contribute to the mental health of undergraduate students, such as: partner status and offline contact, personality traits, social media and streaming platforms usage. There were differences regarding the mental health status indicated by endpoints between: genders, living environment, owning a pet, etc. This study describes how mental health, a neglected subject in the Romanian public health arena, is influenced by various factors during lockdowns. Further research should be conducted and appropriate measures should be taken to prevent the degradation of mental health in medical students under pandemic circumstances.