Adipocytic tumors represent the largest single group of mesenchymal tumors, due to the high prevalence of lipomas and angiolipomas. Liposarcomas are histologically divided into five subtypes: myxoid, pleomorphic, dedifferentiated, round cell and atypical lipomatous tumor (well-differentiated liposarcoma). Atypical li-pomatous tumor (ALT) is the most common histological subgroup, they account for 40% to 45% of all liposarcomas. Well-diff erentiated (WD) liposarco-mas are locally aggressive but incapable of metastasis. Approximately 75% develop in the deep soft tissue of the limbs, followed by 20% in the retroperitoneum and a much smaller percentage in the inguinal region and the mediastinum. They are usually diagnosed after the fifth decade of life, with a slight male predominance re-ported. Atypical lipomatous tumor is an intermediate (locally aggressive) neoplasm composed either entirely or in part of a mature adipocytic proliferation showing significant variation in cell size, atypical stromal cells and a limited number of scattered monovacuolated or multivacuolated lipoblasts. [...]

The lung cancer is the leading cause of death determined by malignancies in the world, followed by breast, prostate and colon cancer. The malignant cells present a variety of genetic aberrations that can be grouped into six essential pathways: (1) the acquisition of self sufficient or autonomous growth signals
(2) insensitivity to growth inhibitory signals
(3) resistance to signals of apoptosis
(4) unlimited proliferation potential
(5) sustained angiogenesis
and (6) invasion and metastasis1.
The p53 protein is a protein with molecular mass of 53 kDa (from where its name derives). The gene p53 encoding the protein p53 is located on the short arm of chromosome 14. The protein p53 is involved in maintaining control cellular genome stability and its disruption can lead to the emergence of malignancies. In about 50% of human cancers, the mutant protein p53 was detected. At the cellular level it regulating the transcription of some genes involved in cell growth control and apoptosis. The gene p53 can be inactivated by punctiform mutations and protein p53 can be inactivated by the formation of complexes with the cellular proteins or by proteolysis.