Introduction: Thyroid diseases have effects on metabolism and inflammation. Adipocytokines have autocrine, paracrine, and endocrine functions on several organs which have a central role in subclinical inflammation of adipose tissue, and obese adipose tissue secretes proinflammatory adipokines such as visfatin, and resistin. Cytokines play a role in the pathogenesis of several autoimmune thyroid diseases. Methods: All samples were conducted at Salah Aldeen General Hospital and the specific private clinic in Tikrit which started from November 2022 to February 2023, the study samples included (30) individuals with hyperthyroidism, (30) individuals with hypothyroidism, and (30) healthy individuals with age (18-76) years. Results: Adipokines (resistin and visfatin) and interleukins (IL10 and IL32) were increased in hypo and hyperthyroidism rather than control. Conclusion: The effect of inflammatory and anti-inflammatory response of some adipokines and interleukins affect the pathogenesis role in thyroid diseases.