The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Doina Anca Plesca

Doina Anca Plesca

Correlation Between Early Diagnosis of Ovarian Neoplasm and Long-Term Prognosis

Ovarian cancer is the seventh most commonly diagnosed cancer in women, with the highest mortality rate among female genital cancers. Due to the nonspecific symptoms and the lack of effective screening strategies, ovarian cancer is often diagnosed in an advanced stage of the disease, with a 5-year survival rate of 25%. The efforts of specialists are aimed at identifying screening methods, with the lowest possible rates of false positive or false negative results in order to diagnose the disease at an early stage, when the 5-year survival rate is 92%. In this study we analyzed the incidence of ovarian cancer in the last five years in the Bucharest University Emergency Hospital, being registered 153 cases of ovarian cancer. The aim of this paper is to analyze the correlation between the early diagnosis of ovarian cancer and the long-term prognosis.

Read More »

A Rare Cause of Recurrent Syncope in the Pediatric Patient

Syncope is type of transient, complete loss of consciousness with an abrupt onset, short duration and complete, spontaneous recovery[1]. It is a frequent symptom in the general population, most patients having a first occurrence between the ages of 10 and 30[2,3]. Strictly considering the pediatric population (under 18 years of age) the reported incidence may be as high as 15%[4]. [...]

Read More »

Vitamin D Levels Correlate with Wheezing and Asthma Recurrence in Children

Vitamin D is a secosteroid with a pivotal role in the calcium and phosphate metabolism, two ions that are essential for bone mineralization, neuromuscular activity and general cell functions. Sources of vitamin D are either endogenous (production in the skin from 7-dehydrocholesterol under the influence of sunlight UV-B radiation) [1] or exogenous (dietary). The dietary forms of vitamin D are either of vegetal origin (ergocalciferol, vitamin D2) [2] or of animal origin (colecalciferol, vitamin D3) [3]. The two calciferol forms are similarly metabolized in humans, have equal bioavailability and effectiveness [4]. [...]

Read More »

Age-Dependent Prevalence of Persistent Wheezing Phenotypes in Romanian Children

Asthma is a heterogeneous group of disease entities with common characteristics such as intermittent respiratory symptoms (wheezing, tightness, cough, dyspnea), reversible airway obstruction and bronchial hyperresponsiveness [1]. Wheezing, caused by airflow restriction through narrowed airways, is the main clinical sign associated with asthma.
Two concepts related to asthma are currently in a process of disentanglement: the concept of asthma phenotypes (particular clinical characteristics, without reference to the underlying pathologic process) and endotypes (pathological mechanisms of disease) [2]. The disentangling of asthma phenotypes and endotypes is important for the prediction of disease evolution and for accurate therapeutic action.

Read More »