Background and objectives: For COVID-19 patients who need effective management, it is necessary to identify the laboratory biomarkers of progression approaching morbidity and mortality. This study aims to demonstrate numerous biochemical tests that seriously afflicted individuals. Such as ferritin, Interleukin-6 (IL6), D-dimer, Uric acid (UA), Lactate dehydrogenase (LDH), and C-reactive protein (CRP) have been proposed as disease biomarkers. Materials and methods: Blood samples were collected from 30 healthy individuals. In addition, other 60 patients confirmed by RT-PCR as COVID-19 positive after 3 to 5 days followed up with them every five days for fifteen days from the beginning of symptoms for the above parameters. All patients attended Isolated Hospital in Tikrit City / Iraq from February to June 2021. Results: Ferritin, D-dimer, IL6, CRP, LDH, and UA gradually increased to the maximum mean (1138±782.7, 1155±400.42, 23.28±4.73, 104.86±53.69, 424.91±95.4 and 5.94±1.765.94±1.76) respectively after (8-10) days and return to normal range after 15 days. Conclusion: There is a significant association of these parameters with inflammatory prognosis in COVID-19 patients.