The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Relevance of Genotyping for the Clinical Management, Transmission and Control Programs of Tuberculosis


More than 130 years after the discovery of its causative agent, TB still produces nearly 9 million new infections and 1.5 million deaths every year (one-quarter among them are patients co-infected with human immunodeficiency virus – HIV)[1]. Th eincidence of TB ranges from less than 10 per 100.000 in North America to 100 – 300 per 100.000 in Asia and Western Russia, to over 300 per 100.000 in Southern and Central Africa. In several regions of the world, the rise of incidence is linked to the increasing impact of HIV epidemics, drug resistant TB and deficiencies of current TB control programs. Th ese reasons determined WHO to declare TB a global emergency in 1993[2]. […]