Background: Dengue infection caused by dengue virus and transmitted through the bite of Aedes aegypti mosquito causes thrombocytopenia due to bone marrow suppression. Increased Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV) values are associated with platelet activation, destruction, and consumption. Hematocrit levels increase due to hemoconcentration that occurs together with plasma leakage, which is common in dengue infection. Leukopenia occurs due to bone marrow suppression, either directly by the virus or indirectly through the production of proinflammatory cytokines.
Objective: Analyzing the relationship between heparanase and hematological parameters in dengue infection patients
Method: Observational analytical study with cross-sectional approach and consecutive sampling data collection in 100 patients. Heparanase levels were examined using enzyme link immunoassay (ELISA), platelet counts, PDW values and MPV values were examined using the impedance method. Hematocrit levels and leukocyte counts were examined using the lowcytometry method. Statistical analysis used the Spearman correlation test (p<0.005).
Results: Heparanase levels were negatively associated with platelet count (r = -0.405, p = 0.001), and positively with PDW (r = 0.250, p = 0.012), MPV (r = 0.247, p = 0.013), and hematocrit (r = 0.269, p = 0.003). However, there was no significant association with leukocyte count (r = -0.077, p = 0.448). Conclusion: There is a weak positive relationship between heparanase levels and PDW values, MPV values and hematocrit levels. There was a weak negative relationship between heparanase levels and platelet counts and there was no significant relationship between heparanase levels and leukocyte counts.
ISSN-online 2360-2473 / ISSN-print 1223-0472
