The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Relationship Between CRP, Procalcitonin, I/T Ratio and The Incidence of Sepsis in Children


Background: Sepsis is body immune response due to infection. Sepsis is a medical emergency condition with high risk of mortality. WHO in 2018 stated that every year there were 2.9 million cases of death due to sepsis. Several markers can be used to support evidence of sepsis in children, such as C-Reactive Protein (CRP), Procalcitonin, and IT ratio. This study will assess 3 markers namely C-Reactive Protein, procalcitonin, and IT ratio that have not found in previous studies.
Aim: To analyse association between inflammatory parameters and the incidence of sepsis in children. Methods: This study is an observational analytic study with a cross-sectional approach that analyses the medical records of paediatric patients in the PICU of RSUP Dr. Kariadi, Semarang from January 2019 – August 2022. The data used are secondary data taken from medical records and then analysed descriptively for patient characteristics. The variables of this study were then analysed bivariate using the chi-square or fisher test then analysed multivariate by logistic regression analysis.
Result: Correlation between C-Reactive Protein levels, Procalcitonin, and IT ratio with the incidence of sepsis in children p<0.001 and nutritional status with incidence of sepsis in children p=0,011. The results of multivariate logistic regression analysis showed that the dominant significant variable was C-Reactive Protein with an OR value of 212.331 and p<0.001.
Conclusion: There is a significant association between inflammatory parameters (CRP, procalcitonin, and IT ratio) with the incidence of sepsis in children. C-Recative Protein is most dominant parameter for sepsis detection in children.