Current Issues in Acute Diarrheal Disease


The intestinal microflora consists of micro-organisms (bacteria required for normal functioning of the digestive tract), which are interacting with the human body (commensalism), the digestive tract is the habitat required for the development of these bacteria, and these, in turn, produce the constituents necessary for the organism. Disruption of this balance makes some ordinary saprophytic species to become pathogenic.
Clostridium difficile(CD), gram positive bacillus, anaerobic, sporulated, enters into the structure of normal enteric resident flora in a proportion of 60-70% in newborns, 10 to 30% in hospitalized patients, and only 3% in healthy adults (1). If this flora is iatrogenic depressed by antibiotic therapy, chemotherapy, inhibitors of gastric acidity, CD wins “vital space”
by multiplying causes damage to the intestinal mucosa and subsequently, on the background of comorbidities, gives the lead of severity to the clinical evolution.