Biomarkers and Imagistic Methods for Early Diagnosis and Prognostic of Laryngeal Cancer


For years, intermediate and advanced staged tumors were approached with total laryngectomy and post-operative RT until 1991, when the Veterans Administration Larynx Study and other subsequent organ preservation trials established the role of chemo radiation in the upfront treatment of intermediate laryngeal cancers (stage III and early IV a).
Surgical management of the larynx and hypo-pharyngeal malignancies have become increasingly challenging as surgical organ preservation strategies are applied. Failures of these protocols are often accompanied by post radiation sequels, which enhance post-surgical complications when a salvaging laryngectomy/laryngopharyngectomy is undertaken.