Radu Ciprian Tincu

Radu Ciprian Tincu

Upper GI Bleeding with Hemorrhagic Shock Caused by Infectious Esophagitis

CMV infection in healthy hosts is generally asymptomatic, producing a latent infection with antibodies persisting for months or even years after the recovery. In the population at risk, CMV infection is one of the most frequent opportunistic infection. The most frequent GI manifestation of CMV infection is colitis followed by esophagitis although it can affect all organs. CMV esophagitis has been reported in immunocompromised hosts by conditions like organ transplantation, bone marrow transplantation, in patients with HIV infection and AIDS or other debilitating diseases. [...]

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Intrathoracic Anastomotic Leak after Ivor Lewis Esophagectomy: Non-Surgical Management

Esophagectomy is the best therapy for the patients with locoregionally advanced esophageal cancer, but carries serious risks of associated morbidity and mortality. Esophageal anastomotic leak is a severe post-operative complication with a rate of mortality that can reach 60%. Clinical presentations of esophageal anastomotic leaks varies from asymptomatic to severe sepsis and death. The prognosis depends on the duration to diagnosis and the severity of contamination. An anastomotic esophageal leak has a great impact on the length of hospitalization, morbidity, stricture formation and dysphagia. The management of intrathoracic anastomotic leaks include conservative, surgical or endoscopic treatment, but the indication between these options of treatment remains controversial. [...]

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Crohn's Disease or Intestinal Tuberculosis. A Diagnostic Challenge

TB usually affects the lungs but many other organs may be involved. Intestinal tuberculosis primarily involves the distal ileum and cecum, followed by the jejuno-ileum, colon and rectum. The development of strictures and fistulas mimic Crohn’s disease, and generalized colonic involvement mimics ulcerative colitis. A 42 year old patient was admitted to the Gastroenterology Department of Emergency Clinical Hospital Bucharest with a 3 months history of unintentional weight loss (15 kg), diarrhea (7-8 unformed stools per day), right iliac fossa pain, night sweats. He had a history of recent fungal esophagitis and antral gastritis. He denied prior contact with patients with tuberculosis and has no pets. [...]

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Review on Non-Invasive Diagnosis of Pancreatic Cancer

The pancreatic cancer has the worst prognosis among gastrointestinal cancers with a mortality rate close to incidence. The analysis on the globe carried out by GLOBOCAN in 2012 places the pancreatic cancer on the 13th place in terms of incidence and on the 8th place in terms of mortality of all cancers and in relation with digestive cancers it occupies the 6th place for both epidemiological indices [1]. [...]

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Can Complementary Feeding Patterns Influence Rapid Weight Gain in Infancy?

Current knowledge based on large randomized con-trolled trials documented so far that early protein intake from milk products, in the first six months of life, is associated with various changes in later outcomes regarding body weight or body composition [1,2]. Beyond the exclusive milk nutrition period, complementary fe-eding practices are less investigated in terms of obesity appearance [3]. Macronutrients supply in early life, such as carbohydrates and fats, do not seem to be implicated in later childhood obesity [4], whereas protein supply is much more studied in the present [5]. Due to rapid weight gain and body size evolution in first 3 years of life, nutritional requirements are high, but exceeding some normal ranges leads to future disturbances. [...]

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Burden of Clostridium Difficile Infection in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract. There is epidemiologic evidence that in patients with IBD, Clostridium difficile infection (CDI) occurs more frequently than in the general population and that these rates have been increasing over the past several decades. [...]

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Blood Lead Levels and Oxidative Stress

Environmental lead sources are represented by air, soil, food, water. Lead distribution in the environment continues to be a worrying public health issue considering its potential cumulative effects in the body due to various routes of exposure. Once exposed to lead, individuals have persistent elevated blood levels because of redistribution from bones sanctuaries, even years after cessation of exposure. Oxidative stress seems to play an important part regarding lead adverse effects, because the metal is responsible for reactive oxygen species (ROS) production and it also might inhibit antioxidants levels [...]

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