Radu Alexandru Macovei

Radu Alexandru Macovei

Crohn's Disease or Intestinal Tuberculosis. A Diagnostic Challenge

TB usually affects the lungs but many other organs may be involved. Intestinal tuberculosis primarily involves the distal ileum and cecum, followed by the jejuno-ileum, colon and rectum. The development of strictures and fistulas mimic Crohn’s disease, and generalized colonic involvement mimics ulcerative colitis. A 42 year old patient was admitted to the Gastroenterology Department of Emergency Clinical Hospital Bucharest with a 3 months history of unintentional weight loss (15 kg), diarrhea (7-8 unformed stools per day), right iliac fossa pain, night sweats. He had a history of recent fungal esophagitis and antral gastritis. He denied prior contact with patients with tuberculosis and has no pets. [...]

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Burden of Clostridium Difficile Infection in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract. There is epidemiologic evidence that in patients with IBD, Clostridium difficile infection (CDI) occurs more frequently than in the general population and that these rates have been increasing over the past several decades. [...]

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Blood Lead Levels and Oxidative Stress

Environmental lead sources are represented by air, soil, food, water. Lead distribution in the environment continues to be a worrying public health issue considering its potential cumulative effects in the body due to various routes of exposure. Once exposed to lead, individuals have persistent elevated blood levels because of redistribution from bones sanctuaries, even years after cessation of exposure. Oxidative stress seems to play an important part regarding lead adverse effects, because the metal is responsible for reactive oxygen species (ROS) production and it also might inhibit antioxidants levels [...]

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