Irritable Bowel Syndrome (IBS) is one of the most common disorders of the gut-brain axis, affecting a significant percentage of the global population. This review article explores the pathophysiological mechanisms of IBS in the context of the biopsychosocial model and neurogastroenterology, emphasizing the impact of motility disorders, visceral hypersensitivity, and altered intestinal microbiota. Recent epidemiological data is presented, highlighting the underdiagnosis of IBS and its increased incidence in young women. IBS management involves a multidisciplinary approach, including dietary modifications, psychosocial therapies, and various pharmacological options. Among these, the combination of alverine citrate with simethicone emerges as a first-line treatment due to its effectiveness in reducing symptoms. New research directions aim at more precise treatment personalization based on intestinal microbiome and specific biomarkers.

Colorectal cancer (CRC) remains a major problem of global health. Screening colonoscopy is the gold standard in detection of CRC. A quality colonoscopy needs good indication, adequate bowel preparation, adequate examination time (30 to 45 minutes), a minimum 6 minutes time for mucosal examination during colonoscopy descent, a good centre adenoma detection rate. In 28-33% of the colonoscopies, the bowel preparation is unsatisfactory which leads to several hidden costs including the rise of preventable and treatable death rate regarding colorectal carcinoma. The ESGE (European Society of Gastrointestinal Endoscopy) recommends a maximum of 10% poor preparations, threshold that is difficult to reach in many centres. Newer low-volume laxative regimens for bowel cleansing are better in the fields of compliance and tolerability than the classic 4L PEG with 2L PEG-CS (Clensia ®) being one of the new promising low-volume formulas. The low fibre diet is now preferred due to better compliance and tolerability. Conclusions: One of the easiest ways to improve colonoscopy quality is through improved compliance. Two of the most effective measures are using newer laxative bowel cleansing formulas (like 2L PEG-CS) and a low-fibre diet.

Interventional radiology has made significant progress to the care of severe acute pancreatitis complications with the introduction of percutaneous procedures. More recently, radiologic intervention has become the gold standard in treating a rare condition like pancreatic pseudoaneurysms. We report the case of an 40 years old male, heavy drinker and smoker, at the second episode of acute pancreatitis that developed an pseudoaneurysm cured through angiographic embolotherapy.