Laurentiu Coman

Laurentiu Coman

The Effect of Timolol on the Iris Vascular Tone in Rats

Vascular tone is generally controlled by both the humoral component and the neuro-vegetative component. Regarding the second one, catecholaminergic sympathetic innervation of blood vessels is almost a rule in the body[1,2].
It is known that the iris is sympathetically inner-vated, both at the level of the iris dilator muscle[1,2] and at the level of iris blood vessels[3]. Cathecolamines are responsible for vasoconstriction and, in some vascular beds, vasodilation. [...]

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The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of..

Histamine and serotonin (5-hydroxytryptamine) are two amino acid derivatives with important biological functions [1]. Histamine, an endogenous monoamine, is synthesized from the histidine and is stored in most tissues and degraded in liver by histaminase. The most important roles of histamine are: mediation of type I allergic reactions, stimulation of stomach secretion of hydrochloric acid and pepsin (as autacoid), and functioning as a neurotransmitter (especially in the central nervous system)[2]. Regarding the vascular effects of histamine in non-ocular territories, there have not been many published literature reviews, for example, there are data reviewed for pulmonary artery[3], brain territory[4], but these data are not recent.

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Can Complementary Feeding Patterns Influence Rapid Weight Gain in Infancy?

Current knowledge based on large randomized con-trolled trials documented so far that early protein intake from milk products, in the first six months of life, is associated with various changes in later outcomes regarding body weight or body composition [1,2]. Beyond the exclusive milk nutrition period, complementary fe-eding practices are less investigated in terms of obesity appearance [3]. Macronutrients supply in early life, such as carbohydrates and fats, do not seem to be implicated in later childhood obesity [4], whereas protein supply is much more studied in the present [5]. Due to rapid weight gain and body size evolution in first 3 years of life, nutritional requirements are high, but exceeding some normal ranges leads to future disturbances. [...]

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Blood Lead Levels and Oxidative Stress

Environmental lead sources are represented by air, soil, food, water. Lead distribution in the environment continues to be a worrying public health issue considering its potential cumulative effects in the body due to various routes of exposure. Once exposed to lead, individuals have persistent elevated blood levels because of redistribution from bones sanctuaries, even years after cessation of exposure. Oxidative stress seems to play an important part regarding lead adverse effects, because the metal is responsible for reactive oxygen species (ROS) production and it also might inhibit antioxidants levels [...]

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The Ethical Implications of Complementary and Alternative Medicine in Systemic Lupus Erythematosus

Lupus erythematosus is an autoimmune disease with multiple symptoms and each patient presents a particular clinical and immunological-biological profile. The cause of the disease remains unknown. Lupus erythematosus embraces three clinical forms: chronic, subacute and systemic. Events in the three clinical forms range from skin involvement (chronic form) to serious systemic implications, affecting patient's health and life (as a systemic disease).
The systemic form - systemic lupus erythematosus - has a wide range of immunological abnormalities that cause inflammation in various organs and systems. The inflammation occurs as a result of excessive production of autoantibodies, that are directed against self structures that are no longer recognized. In systemic lupus, cutaneous manifestations are often accompanied by renal, cardiac, osteoarticular, neuropsychiatric disorders.

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Zinc and Androgen Hormones in Benign Prostatic Hyperplasia

Prostatic pathology represents one of the most common causes of dermato-urological addressability, because of the varied age interval, but also because of the symptoms that decrease rapidly and visibly the patients’ quality of life. Benign prostatic hypertrophy (BPH) is represented by increased volume of the prostate, which generates an obstructive and irritative symptomathology in the pelvic urinary tract. The hormonal influence presents a certain contribution in the development and evolution of BPH, by the imbalance occurred between androgens and estrogens, revealed by the significant decrease of the ratio androgens/estrogens hormones and by the inflammatory factors (1,2,3,4).

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