Ion Dina

Ion Dina

Diagnostic Challenges in Atypical Pulmonary Carcinoid

The spectrum of neuroendocrine tumors (NETs) of the lung is wide and heterogeneous, ranging from well-differentiated bronchial neuroendocrine tumors to highly malignant and poorly differentiated small cell lung cancer and large cell neuroendocrine carcinoma. NETs of the lung share both morphologic and immunohistochemical characteristics with neuroendocrine tumors. [...]

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Worsening Renal Function in Elderly Patients with Heart Failure and Chronic Kidney Disease: An Update

Chronic kidney disease (CKD) is defined as either kidney damage or eGFR (estimated glomerular filtration rate) < 60 mL/min/1.73 m2 for three or more months [1]. Elderly patients have often an impaired basal renal function due to intrinsic renal disease or to a physiological decrease in the number of functional nephrons [2]. Half of adults over the age of 70 years have eGFR < 60 mL/min/1.73 m2 [3]. CKD occurs in about 4.5% of the general population and 50% in patients with chronic or acute heart failure (HF) [4]. Commonly, CKD can be associated with chronic heart failure in elderly patients [2] [...]

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