Dragos-Constantin Lunca

Dragos-Constantin Lunca

The Effect of Timolol on the Iris Vascular Tone in Rats

Vascular tone is generally controlled by both the humoral component and the neuro-vegetative component. Regarding the second one, catecholaminergic sympathetic innervation of blood vessels is almost a rule in the body[1,2].
It is known that the iris is sympathetically inner-vated, both at the level of the iris dilator muscle[1,2] and at the level of iris blood vessels[3]. Cathecolamines are responsible for vasoconstriction and, in some vascular beds, vasodilation. [...]

Read More »

The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of..

Histamine and serotonin (5-hydroxytryptamine) are two amino acid derivatives with important biological functions [1]. Histamine, an endogenous monoamine, is synthesized from the histidine and is stored in most tissues and degraded in liver by histaminase. The most important roles of histamine are: mediation of type I allergic reactions, stimulation of stomach secretion of hydrochloric acid and pepsin (as autacoid), and functioning as a neurotransmitter (especially in the central nervous system)[2]. Regarding the vascular effects of histamine in non-ocular territories, there have not been many published literature reviews, for example, there are data reviewed for pulmonary artery[3], brain territory[4], but these data are not recent.

Read More »