Background: Chronic Kidney Disease (CKD) describes abnormal structural and functional kidney conditions that mark a decrease in GFR. Erythropoietin producing peritubular cells are partially or completely damaged by the severity of kidney disease, causing inadequate erythropoiesis and anemia. Anemia is one of the factors causing erythrocyte size variations assessed by the red cell distribution width (RDW). The relationship between GFR kidney function and RDW is currently little studied, this encourages researchers to conduct a study of the correlation between GFR and RDW in patients with chronic kidney disease. Methods: Retrospective observational analytic study with cross sectional approach was conducted in 45 chronic kidney disease patients in RSUP dr. Kariadi Semarang in December 2018-January 2019. Data include age, weight, urea and creatinine serum, and RDW. Calculation of GFR values using the Cockroft Gault formula. Statistical tests using Spearman’s correlation, p<0.05 were considered significant. Results: The median (minimum-maximum) GFR and RDW are respectively 20 (6-35) mL/min /1.73 m2; 15.7 (12.8-20.6)%. The correlation test of GFR with RDW is r = -0.468 with p=0.001. Ureum, creatinine and RDW have significant different in chronic kidney disease between stadium 3, 4, and 5 (p=0.001). Conclusion: There is a moderate negative correlation between GFR and RDW in patients with chronic kidney disease. Red cell Distribution Width (RDW) can be used as a altern

Background: The prevalence of obesity and overweight in Indonesian women will continue to increase. Obesity and overweight conditions are often associated with low-grade inflammatory conditions and metabolic syndrome. The ratio of monocytes to HDL cholesterol (RMH) and the ratio of monocytes to lymphocytes (RML) are easy tests to monitor inflammation associated with increased body mass index and cardiovascular disorders due to metabolic syndrome.
Objective: To analyze the differences in RMH and RML in obese and overweight women.
Methods: The cross-sectional study was conducted in the outpatient laboratory at the Diponegoro National Hospital (RSND). This study included 55 overweight women (BMI 25.00 – 29.99 kg/m2) and 55 obese women (BMI ≥ 30 kg/m2), healthy, aged 25-45 years. Research subjects were excluded with the criteria of not having hypertension, liver disorders, and diabetes mellitus. RMH is obtained by dividing the absolute monocyte count by HDL cholesterol. RML is obtained by dividing the absolute monocyte and lymphocyte counts. Monocyte and lymphocyte numbers were obtained by examining a Complete Blood Count (CBC) using an automatic hematology analyzer. HDL cholesterol levels were measured by enzymatic methods using a clinical chemistry analyzer. Statistical analysis with the Mann-Whitney test.
Results: There is a difference in RMH between obese and overweight women (p = 0.003). There was no difference in RML (p = 0.342) between the two groups.
Conclusion: Obese women have a significantly higher RMH than overweight. RMH can be used as an assessment of inflammatory conditions and is used as a clinical alert for various health problems in obese and overweight women.