The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Catalin Alius

Catalin Alius

Diagnostic Challenges and Multimodal Treatment in Primary Peritoneal Cancer: a Case Report

Peritoneal cancer (PPC), a rare and aggressive malignancy, can develop from the peritoneal lining or as a secondary peritoneal cancer caused by metastases from neighbouring organs such as the ovaries, gastrointestinal tract, or breast. Early identification is still difficult due to its ambiguous signs, ranging from bloating, distension, and stomach pain. Due to their comparable histological and clinical characteristics, PPC and ovarian cancer are frequently misdiagnosed. Advanced imaging, histological investigation, and immunohistochemical markers are essential for accurate diagnosis. In order to control any remaining disease and enhance results, treatment usually encompasses an assortment of therapeutic approaches, such as hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgical procedure (CRS). We present a 69-year-old woman who got diagnosed with PPC after first being suspected of having ovarian cancer. The current instance emphasizes how crucial a thorough diagnostic process is to differentiating PPC from related cancers.

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The Multidisciplinary Approach to Vaginal Leiomyosarcoma, an Extremely Rare Diagnosis - Case Report

Primary vaginal sarcoma is an extremely rare malignant condition within the field of gynecological pathologies. We present the case of a 53-year-old patient with no history of gynecological issues or associated comorbidities who presented to our clinic with recurrent vaginal bleeding during menopause. We want to emphasize the importance of diagnostic management, going through all the necessary steps from local gynecological examination to vaginal biopsy, optimizing results with advanced imaging techniques. Once the histopathological diagnosis of vaginal leiomyosarcoma was established, the therapeutic approach was discussed within a multidisciplinary committee consisting of a gynecologist, surgeon, and oncologist. As a result, the patient underwent tailored surgical intervention relatively quickly after presentation, followed by referral to the oncology department, where she is currently undergoing her third course of adjuvant chemotherapy. Our current objective is the long-term follow-up of the patient and the acquisition of data regarding her survival and quality of life. These facts may contribute in the future to the implementation of standardized therapeutic guidelines for such a rare condition. Keywords: vaginal sarcoma, malignant condition, vaginal leiomyosarcoma, surgical intervention, chemotherapy.

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