Bogdan Marinescu

Bogdan Marinescu

Cervical Endometriosis – Case Report and Review of Literature

Endometriosis became a public health problem both due to the increasing number of affected patients and the severe quality of life impairment. Cervical endometriosis is defi ned as the presence of endometrial glands and stroma at cervical level. Primary and secondary cervical endometriosis are two separates entities that require distinct management. Symptomatic cases diagnosed with primary cervical endometriosis have indication for ERAD while patients with secondary cervical endometriosis should be referred to a specialized center because the surgical treatment may imply a high degree of diffi culty. We present a 24-year-old woman with no history of cervical interventions, first diagnosed with cervical displasia and referred to our center for a second opinion. Secondary cervical endometriosis and vaginal endometriotic nodule were diagnosed. Following the general consensus for the benefits of surgery for endometriosis associated with pelvic pain, the patient was considered a candidate for laparoscopic surgery. Complete resection of the endometriotic tissue including the vaginal nodule with laparoscopic suture of the vaginal wall was realized. Laparoscopic surgery for endometriosis is proven to improve the patients’ quality of life, diminishing the symptoms and increases the likelihood of obtaining a spontaneous pregnancy. The presented case illustrates the benefi ts of surgery for secondary cervical endometriosis with marker improvement in quality of life proven with EHP-30 up to 2 years after surgery.

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Cytostatic Therapy on Tumor Bearing Mice: Biochemical and Hematological Aspects

to emphasize this statement mice are used due to human DNA similarity (According to The Jackson Laboratory over 95% of the mouse genome is similar to our own, making mouse genetic research particularly applicable to human disease), simplicity in procurement, handling and short lifespan [1-3]. The purpose of this information is to help investigators who pursue an economical and efficient research that still allows the achievement of the study goals [4-7] [...]

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Multiple Benefic Effects of the Systemic Exposure to the Hydroxychloroquine Sulfate

In the twentieth century, the widespread use of quinacrine by the U.S. military as malaria prophylaxis was accompanied by other observations suggesting efficacy for treatment of rheumatologic diseases [1].
During the 1950s, the hydroxychloroquine (HCQ) derivative of quinacrine showed a favorable usage profile with less eye toxicity than chloroquine itself, and the use of this agent in the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) has become common. In RA, HCQ is usually a component of a drug combination, including triple drug therapy with methotrexate and sulfasalazine, a formula which was claimed as a safe alternative, well tolerated compared to expensive biological therapies [2].

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