Bogdan Alexandru Popescu

Bogdan Alexandru Popescu

Important Aspects to Take Into Consideration When Administering Cytotoxic Chemotherapy. A Review

In the last decade, huge efforts have been made to optimize and personalize oncological treatment. Many novel therapies and better combinations of older ones have been implemented. Even if novelty is always exciting, one has take into consideration that the way a drug is administered is as important as the drug itself. The present review focuses on how the administration of several cancer drugs can minimize the toxicity they induce. It stresses that if enough importance is given to this aspect, patients can tolerate effective doses of treatment with better outcomes and have better quality of life. [...]

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Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: a Borderline Malignancy Tumor

Adipocytic tumors represent the largest single group of mesenchymal tumors, due to the high prevalence of lipomas and angiolipomas. Liposarcomas are histologically divided into five subtypes: myxoid, pleomorphic, dedifferentiated, round cell and atypical lipomatous tumor (well-differentiated liposarcoma). Atypical li-pomatous tumor (ALT) is the most common histological subgroup, they account for 40% to 45% of all liposarcomas. Well-diff erentiated (WD) liposarco-mas are locally aggressive but incapable of metastasis. Approximately 75% develop in the deep soft tissue of the limbs, followed by 20% in the retroperitoneum and a much smaller percentage in the inguinal region and the mediastinum. They are usually diagnosed after the fifth decade of life, with a slight male predominance re-ported. Atypical lipomatous tumor is an intermediate (locally aggressive) neoplasm composed either entirely or in part of a mature adipocytic proliferation showing significant variation in cell size, atypical stromal cells and a limited number of scattered monovacuolated or multivacuolated lipoblasts. [...]

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Obstructive Jaundice of Malignant Origin

Obstruction of the billiary tree caused by a malignant tumor of the head of the pancreas, of the extrahepatic bile ducts or of the ampula of Vater it seems to become more frequent in Romania. Our country places 10th in the incidence and 9th in mortality in Europe for pancreatic cancer in male patients[1]. Unfortunately most of the patients are not suited for a curative surgical treatment at the moment of the diagnosis.

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Renal Artery Stenosis - Review Upon Current Diagnosis and Endovascular Treatment in Light of Recent Studies

Renal artery stenosis represents the main cause of secondary hypertension and, due to its progressive profile, leads to end-stage renal disease and important cardiovascular events (1). Despite the large number of trials in this particular field of interest, RAS therapy remains a complex challenge for clinicians with regard to interventional revascularization, eventually resulting in renal function preservation, improved blood pressure control (BP) and prevention of adverse cardiovascular events in selected patients (2).
In fact, the matter of debate is represented by the proper selection of patients which would benefit the most from renal revascularization with stent implantation, while also taking into account the outcomes of the recently emerging large clinical trials that were unable to confirm the clear benefits of endovascular therapy.

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