The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Alexandra Ana Maria Stanescu

Alexandra Ana Maria Stanescu

Lipid Profile of the Patient with Acute Coronary Syndromes Undergoing Coronary Angiography (CAG) in Rural Costal Region of Maharashtra

Background: Coronary Heart Disease (CHD) is widely prevalent across the globe and significantly high level of Cholesterol in circulation is a single major risk factor associated with coronary heart disease. It is well established that cardiovascular disease is associated with hypertension and elevated blood levels of low-density lipoprotein (LDL), total cholesterol, and triglycerides. In disparity, a low level of high-density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Aim: The present study was conducted with the aim to assess the lipid profile in patients of Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) in rural coastal population. Patients and Methods: The present study was done on 62 patients with Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) Serum levels of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were examined in biochemical laboratory of the hospital. Coronary angiography was performed for the presence of lesions. Results: 43.5% of the patients (n=27) were elderly (age>60 years). Approximately 82% of the patients (n=51) aged more than 50 years. Males outnumbered females with a ratio of 2.4:1. 71% of the patients were males.
Mean cholesterol levels were 177.86 mg/dl. Approx 3/4th of the patients (n=41) had cholesterol level <200 mg/Dl. Mean triglycerides levels in the patients were 158.29 mg/dl. Only 11 patients out of 62 CAD patients had abnormal triglycerides. Mean LDL level was 119.5 mg and Mean HDL level was 34.5 mg %. The high plasma concentration of low-density lipoprotein (LDL-C) in 30% and the low plasma concentration of high-density lipoprotein (HDL-C) n 33% of patients were important abnormal findings in our patients. Conclusion: Dyslipidemia as in form of very low levels of HDL cholesterol with comparatively high levels of LDL-c with near normal total Cholesterol and triglyceride levels associated with ACS in our rural costal region of Maharashtra.

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Metabolic Syndrome. Particularities During SARS-CoV-2 Infection

The COVID-19 pandemic is a significant public health crisis as the coronavirus continues to rapidly spread with long-term socioeconomic consequences. Another malady, although non-transmissible, also a significant health hazard is the metabolic syndrome, which has widespread globally, being classified as an epidemic as the western lifestyle expands worldwide. The SARS-CoV-2 causes systemic inflammation similar to obesity; nevertheless, the coronavirus causes an unregulated rise in cytokine secretion, resulting in multiple organ failures and death. Increasing evidence demonstrates that obesity aggravates the COVID-19 disease and its mortality, the four most prevalent comorbidities of COVID-19 being hypertension, diabetes, cardiovascular, and respiratory disease, all of them tightly associated with obesity. This paper reviews the physiopathological processes that constitute the metabolic syndrome and the molecular mechanisms through which the coexistence of MetS can contribute to the pathogenicity of COVID-19 and an unfavorable outcome of the disease.

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Oral Pathology in Digestive Diseases

Correlations between alterations in the oral cavity and systemic conditions have been widely reported. A considerable number of gastrointestinal (GI) diseases of varied nature may produce lesions in the hard and soft oral tissues. Among the different types of manifestations of GI, oral lesions represent an important, if not a major component of the manifestation of these diseases. As a consequence, recognition and management of oral lesions accompanying the GI conditions, is mandatory for all clinicians, either gastroenterologists or dentists. The aim of this article is to underline useful data about the most common GI conditions (intestinal bowel diseases (IBD), gastroesophageal reflux, genetic diseases, malabsorption conditions, infections, metastatic tumors) and their link to oral pathology.

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Telemedicine in Europe - Current Status and Future Perspectives

Telemedicine ensures remote medical services through technologies that facilitate the interaction between a health professional and patients and offers the possibility of a interdiciplinary consultation between specialists, in order to obtain a diagnosis and treatment plan. It involves secure transmission of medical data and information, through text, sound, images or other forms needed for the prevention, diagnosis, treatment and follow-up of patients. With the help of telemedicine, people from rural areas, with dificult access to primary care, and those with reduced mobility can benefit from healthcare services. This paper is a review of the latest data available in the literature regarding telemedicine and the future prespectives in this field in Europe.

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Trace Elements and Cancer

The role of the trace elements in humans has increased during the last 20 years. It seems that they play a significant role in maintaining the healthy state of the organism. These minerals are present in small levels, but their role is vital. Although they account for only 0.02% of the total body weight, it has highlighted that they play significant roles, either as active centers of enzymes or as trace bioactive substances. Their excess or deficiency may influence the homeostasis and potentially can lead to several chronic diseases, including cancer. It is already known that certain elements in the free or combined state can be primary causative agents, or risk factors for human cancer. Nevertheless, it is important to underline that the carcinogenic elements are fewer than it was expected in studies. Copper, cobalt, chromium, zinc, selenium, are involved in many biochemical processes supporting life. However, their concentrations may play an important role in developing cancer, by influencing proliferation or apoptosis. Disruption of the balance between free radicals and antioxidants may cause a cellular damage and trigger carcinogenesis.

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Contraindications to Breastfeeding - Current Issues at the Border Between Myth and Reality

Breast milk is recommended as an optimal and exclusive source of early nutrition for all infants from birth to at least 6 months of age. Despite all the benefits of breastfeeding, there are situations where breastfeeding is contraindicated. There are differences of opinion regarding the contraindications of breastfeeding, the current research bringing more knowledge in this area. It is important to know the differences of opinion for the correct approach of the breastfeeding patient.

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Alcohol Withdrawal Syndrome: a Review

Alcoholism is a common condition and frequently clinicians are forced to confront its complications in general hospital settings. Within each country, there is an excellent correlation between the level of alcohol consumption and the prevalence of alcohol-related harm. In fact, the consumption in Europe is 10.9 liters of pure alcohol per person per year[1]. There are an estimated 3 million alcohol-dependent people in Romania alone, with episodes of withdrawal severe enough to require pharmacologic treatment[1]. [...]

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