In the 1990s a sampling team from the Surgery Department of Saint Luc Clinic in Louvain Brussels, published a study showing that single aortic infusion is as safe as classic, standard infusion (aortic and portal) but the attempt was not fully accepted. Also, some recent studies recommend the safe use of single aortic infusions in the case of multiple organ sampling from the brain-dead donor. In order to test the effectiveness of this method we made a retrospective study between 2017 and 2019 at the Center for General Surgery and Liver Transplantation of the Fundeni Clinical Institute, Bucharest, Romania. First of all, we performed a comparative analysis between the single aortic sampling group and the group in which we used the standard sampling. We also analyzed the impact of singular aortic sampling on cases with anatomical arterial variants.