The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Thursday, October 18 2018 @ 11:49 EEST

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Vertebral Synovial Sarcoma - Onset with Spinal Cord Compression Syndrome. Case Report

2016-03

Laura Rebegea, Dumitra Miron, Mihaela Dumitru, Dorel Firescu, Mary Lupu, Rodica Anghel

Synovial sarcomas (SS) are rare. Less than 5% occur in spine, mediastinum, head and neck and at the retroperitoneal level and in approximately 85% of the cases occur at the level of the soft tissues and extremities. SS metastases are not rare, they occur predominantly at the level of lungs, bones and liver. Standard treatment consists in surgery, ideal, in large excision with negative margins, R0 (when is possible). For unresectable tumors, the therapeutic options include CMT and/or RTE [2]. [...]

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Adenocarcinoma of Duodenum - Case Report

2016-03

Amelia Genunche-Dumitrescu, Daniela Badea, Mihail Badea, Paul Mitruț, Vlad Pădureanu, Aurelian Adrian Badea

Primary duodenal carcinoma represent 35-45% of all tumors in the small bowel but he has a small share in all gastro-intestinal tumors (0.35%) [1,2]. The most frequent type of tumor in the duodenum is the adenocarcinoma, but can observed other types of tumours such as lymphomas, carcinoid tumors, gastrinomas, leiomyo-sarcomas and stromal tumors [3]. The localization of the primary duodenal adenocarcinomas is in the first and second level of the duodenum, and 20% and 10% remain in the next two levels. [...]

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Serum Troponin - a Sensitive Indicator of the Cardiac Involvement in Septic States

2016-03

Andrei Seri, Adrian Madalan, Isabela Tiglea, Daciana Marta

Troponins (Tn) are protein associations located on the filaments of the movement-generating apparatus in the striate (both cardiac, and skeletal) musculature. There are three distinct proteins coded by separate genes: TnC, TnI, TnT. Th ey are important regulatory components of the myocardial contraction machine. Their nomenclature reflects the role each of them plays in contraction [1]. [...]

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Crohn’s Disease or Intestinal Tuberculosis. A Diagnostic Challenge

2016-03

Alina Constantin, Madalina Ilie, Daniela Tabacelia, Bogdan Popa, Gabriel Constantinescu, Radu Tincu, Radu Alexandru Macovei

TB usually affects the lungs but many other organs may be involved. Intestinal tuberculosis primarily involves the distal ileum and cecum, followed by the jejuno-ileum, colon and rectum. The development of strictures and fistulas mimic Crohn’s disease, and generalized colonic involvement mimics ulcerative colitis. A 42 year old patient was admitted to the Gastroenterology Department of Emergency Clinical Hospital Bucharest with a 3 months history of unintentional weight loss (15 kg), diarrhea (7-8 unformed stools per day), right iliac fossa pain, night sweats. He had a history of recent fungal esophagitis and antral gastritis. He denied prior contact with patients with tuberculosis and has no pets. [...]

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The Vasopressin System in Metabolic Syndrome and Insulin Resistance - a Mini-Review

2016-03

Madalina Vintila, Mihail Coculescu, Florin Grigorescu, Catalina Poiana

Metabolic syndrome (MetS), type 2 diabetes, and consequent cardiovascular complications are serious healthcare problems worldwide [1,2]. The prevalence of MetS or its components around the world is variable in different ethnic populations [3,4], and this can be explained by interactions between susceptibility genes specifically expressed in certain ethnic groups and environmental factors [5]. Nonetheless, the number of people aff ected by these conditions is continuously increasing at a global level [4,6] and along with it the mortality and morbidity of populations [7,8]. Cardiovascular disease (CVD) is the main cause of mortality in people suffering from MetS and/or diabetes [9]. The research in this field is ongoing, in the attempt to elucidate the pathophysiological mechanisms and pathways involved in MetS, and to find reliable biomarkers for diagnosis and disease prognosis, as well as therapeutic targets. [...]

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Review on Non-Invasive Diagnosis of Pancreatic Cancer

2016-03

Iulia Petre, Coralia Bleotu, Madalina Ilie, Radu Tincu, Bogdan Popa, Gabriel Constantinescu

The pancreatic cancer has the worst prognosis among gastrointestinal cancers with a mortality rate close to incidence. The analysis on the globe carried out by GLOBOCAN in 2012 places the pancreatic cancer on the 13th place in terms of incidence and on the 8th place in terms of mortality of all cancers and in relation with digestive cancers it occupies the 6th place for both epidemiological indices [1]. [...]

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Recent Advances in the Genetics of Pheochromocytomas and Paragangliomas

2016-03

Alexandra Mirica, Ioana Anca Badarau, Radu Mirica, Sorin Paun, Catalina Poiana, Diana Loreta Paun

Pheochromocytomas (Pheos) and paragangliomas (Pgls) are rare neuroendocrine tumors, with the same embriologic origin. Based on WHO classification, chromaffin tumors of the adrenal medulla are called Pheos, whereas tumors arising from extra-adrenal chromaffi n cells, along the autonomous nervous chains, are named Pgls [1]. Furthermore, there are two types of Pgls according to their homologous nervous chain: sympathetic and parasympathetic tumors. Sympathetic Pgls are developing from the pre- and paravertebral sympathetic ganglia (ex: Pgls of the thorax, mediastinum, abdomen) and from the connective tissue within the pelvic organs (ex:urinary bladder Pgl). They release dopamine or norepinephrine (NE) because they lack phenylethanolamine N-methyltransferase (PNMT), the enzyme in charge of transforming NE into epinephrine (E), that is specific to adrenal medulla. [...]

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Osteosarcoma in Children and Adolescents - a Single Center Review of Presentation, Therapy and Outcome

2016-03

Razvan-Cosmin Petca, Stefan Gavriliu, Gheorghe Burnei

Worldwide, cancer is the second leading cause of death, following heart disease, accounting for 23% of all deaths. Although most cancers causing death are carcinomas of lung, prostate and breast, primary malignancy of the bone is ranked as the third leading cause of death in patients with cancer who are younger than 20 years [1]. [...]

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A Long Term Clinical Comparison in Cases of High Volume Benign Prostatic Obstruction - Bipolar Plasma Enucleation Versus...

2016-03

A Long Term Clinical Comparison in Cases of High Volume Benign Prostatic Obstruction - Bipolar Plasma Enucleation Versus Standard Prostatectomy

Catalin Bulai, Petrisor Geavlete, Cosmin Ene, Ovidiu Bratu, Ileana Peride, Andrei Niculae, Bogdan Geavlete

Despite the constant technological advances achieved during the past decades, large size benign prostatic hyperplasia (BPH) pathology continues to raise questions concerning the most appropriate therapeutic approach. Interestingly enough, the classical open prostatectomy still represents the standard option for this type of cases despite the substantial perioperative morbidity [1]. [...]

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Outcome of Children with Acute Lymphoblastic Leukemia Treated with the ALL-BFM 95 Protocol during 2001-2014 at the Pediatric...

2016-03

Outcome of Children with Acute Lymphoblastic Leukemia Treated with the ALL-BFM 95 Protocol during 2001-2014 at the Pediatric Hematology Center from Tirgu-Mures

Adrienne Horvath, Zsuzsanna Erzsebet Papp, Mihaela Chincesan, Maria Despina Baghiu

Acute lymphoblastic leukemia (ALL) is responsible for 25% of all childhood cancers. The outcome has dramatically changed during the last decades, reaching an overall survival rate of approximately 80% in high-income countries and lower rates in low and middle-income countries [1-6]. Recent trials with risk stratifi cation based on biological features of leukemic cells and response to therapy report an even better survival rate of 90% [7].

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Vitamin D Levels Correlate with Wheezing and Asthma Recurrence in Children

2016-03

Marius Cornitescu, Gabriel Mircescu, Mariana Moiceanu, Eugenia Buzoianu, Vlad Plesca, Andrei Zamfirescu, Doina Anca Plesca

Vitamin D is a secosteroid with a pivotal role in the calcium and phosphate metabolism, two ions that are essential for bone mineralization, neuromuscular activity and general cell functions. Sources of vitamin D are either endogenous (production in the skin from 7-dehydrocholesterol under the influence of sunlight UV-B radiation) [1] or exogenous (dietary). The dietary forms of vitamin D are either of vegetal origin (ergocalciferol, vitamin D2) [2] or of animal origin (colecalciferol, vitamin D3) [3]. The two calciferol forms are similarly metabolized in humans, have equal bioavailability and effectiveness [4]. [...]

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Two-Dimensional Speckle Tracking Echocardiography - a Useful Non-Invasive Method in Predicting Significant Coronary Artery...

2016-03

Two-Dimensional Speckle Tracking Echocardiography - a Useful Non-Invasive Method in Predicting Significant Coronary Artery Disease in Low Risk Acute Coronary Syndrome

Roxana Onut, Monica Stoian, Sebastian Onciul, Diana Zamfir, Cristina Marinescu, Ioana Petre, Silvia Iancovici, Alexandra Paval, Alexandru Scafa, Lucian Calmac, Vlad Bataila, Maria Dorobanțu

Echocardiography is the first cardiac imaging technique used to evaluate patients presenting with acute coronary syndrome (ACS). However, in the absence of wall motion abnormalities, conventional echocardiography at rest provides little information. Patients presenting with low risk ACS usually have normal wall motion and left ventricle ejection fraction (LVEF) at rest.

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